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KMID : 0854720090290010053
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 1 p.53 ~ p.59
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The Effect of Anti-IgE Antibody on Airway Inflammation in a Mouse Model of Chronic Asthma
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Hong Tai-Yong
Park Sung-Hak
Kim Ju-Sang
Lee Sook-Young
Kim Seung-Joon
Kim Young-Kyoon
Kang Ji-Young
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Abstract
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Background: Asthma is a disease characterized by chronic airway inflammation and airway hyperresponsiveness. Immunoglobulin E (IgE) plays a key role in the pathogenesis of allergic diseases and asthma. Recently, nonanaphylactogenic antihuman IgE antibody has been used as a therapeutic agent for asthma.
Objective: The present study investigated the effect of anti-IgE antibody on the airway inflammation and hyperresponsiveness (AHR) in a mouse model of chronic asthma.
Method: We developed a mouse model of chronic asthma for which ovalbumin (OVA)-sensitized female BALB/cmice were repeatedly exposed to intranasal OVA administration twice a week for 3 months. Anti-IgE antibodies
were intravenously administered starting on the 38th day, the next day after 3 challenges and there after once a month during the intranasal OVA challenge of 3 months.
Result: Mice chronically exposed to OVA developed sustained eosinophilic airway inflammation and AHR to methacholine compared with control mice. Treatment with anti-IgE antibody inhibited the development of AHR and eosinophilic inflammation. Moreover, anti-IgE antibody treatment reduced the interleukin-5 and interleukin-13 in bronchoalveolar lavage fluid but did not show the change in interleukin-10 and transforming growth factor-β1 levels.
Conclusion: These results suggest that anti-IgE treatment can modulate airway inflammation via regulation of Th2
cytokines.
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KEYWORD
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Asthma, Anti-IgE antibody, Th2 cytokine
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